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Cymbalta Description, cymbalta is an antidepressant medication that works as a serotonin and noradrenaline reuptake inhibitor to treat major depressive disorder. Get emergency medical help, immediately. Cymbalta may also increase chances of: suicidal thoughts, especially in patients younger than 24 years old mood changes increased pressure on your eyes (narrow-angled glaucoma) impaired thinking and/or reactions bleeding when taken with other nsaid medications complications in your pregnancy and. Combining certain medications can change how Cymbalta will work for you or cause unwanted side effects. Consult with your doctor about the risks of taking Cymbalta medication while you are pregnant, may become pregnant, or are breast feeding. Ships from the UK, cymbalta ( duloxetine ) is an snri (serotonin-norepinephrine reuptake inhibitor) which has been used since the 1990s in patients with depression or anxiety. 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